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TLR4 can enhance the production of pro-inflammatory cytokines and chemokines, such as IL-6 and IL-17, by binding with exogenous ligands, like peptidoglycan, in FLS and peripheral blood mononuclear (PBMC) from RA patients, and trigger cartilage inflammation and degeneration (135)

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Chen W-H, Xu X-D, Luo G-F, Jia H-Z, Lei Q, Cheng S-X, et al

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