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Conflicts of interest The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or non-financial in this article

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While some studies have shown benefits in primary prophylaxis with lactulose [60], current guidelines do not recommend the routine use of lactulose as primary prophylaxis for HE [61]

In WT mice, systemic inhibition of DPP-4 activity, which inhibited plasma DPP-4 activity by about 90%, improved lipid tolerance and increased plasma active GLP-1 levels by approximately 4.5-fold in HFD-fed mice (Figure 5)