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AOD-9604 is unique in combining direct fat cell targeting through beta-3 receptor modulation with absence of systemic growth hormone effects

2008;337:a2332

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However, the use of animal models is expensive, requires a lot of time and expertise, has low throughput potential, poses ethical issues, but most importantly, these models often do not correlate to human systems (Barr-Sinoussi and Montagutelli 2015)