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IF also reduces GH metabolic clearance and heightens lipolytic responsiveness, while attenuating IGF-I bioactivity and downregulating JAK/STAT signaling, as evidenced by decreased phospho-STAT5b/STAT5b ratios [22, 23]

doi: 10.1038/nature13135 208 SalzmanN

BANT (British Association for Nutrition and Lifestyle Medicine), 2024

One of these pathways is pivotal route of PI3K/Akt cascade, as is an obvious regulatory mechanism for cell survival, proliferation, and metabolism [55], which is directly stimulated via FSHR, after directly interacting with adapter proteins of 14-3-3 [56]

Other than that, glutamine supplements are important in gut function, immune function, etc