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Iron overload reduces CaV1.3-dependent L-type Ca 2+ currents ( 2+ leaks through the Ca 2+ release channels (62), sarcoendoplasmic reticulum Ca 2+ -ATPase activity is inhibited, the sodium-calcium exchanger currents are elevated (63), and L-type calcium channels are reduced (64, 65)

One more thing worth flagging: media coverage in India has pointed out that the push toward quick-fix injectable "whitening" is especially common in Tier-2 and Tier-3 cities, often without proper medical evaluation