Gastrointestinal Tract (GIT) and Food Intake In the GIT, GLP-1 reduces gastric motility, inhibits postprandial gastric acid secretion, decreases postprandial pancreatic exocrine secretion and reduces smooth muscle activity in the small intestine, 194 promoting a slower digestion of nutrients from the GIT
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However, it is noteworthy that resmetirom showed an improvement in certain liver pathology measurements in only 2530% of patients
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Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation, because of the link between GLP-1 release and nausea, and the link between PYY release and postprandial fullness ( In summary, there is a clear need for in-depth evaluation of release of GI peptides after a standard meal in larger sample sizes of Rome IV PDS and EPS and gastroparesis patients
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