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In addition to their neuroprotective role, GLP-1 analogs have also been studied for their influence on spinal excitatory synaptic transmission under pathophysiological conditions such as neuropathic pain

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Advanced stages of NASH are thought to be triggered by multiple, synergistic mechanisms including insulin resistance, genetic and epigenetic factors, mitochondrial mutations and dysfunction, adipokines, the microbiome (gut-liver axis), and diet (Buzzetti et al., 2016)

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