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The National Cancer Institute warns that "too many enemas of any kind can cause changes in normal blood chemistry, chemicals that occur naturally in the body and keep the muscles, heart, and other organs working properly." Some experts specifically warn against using coffee as the stimulant in an enema, citing a lack of research on its potential effects

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One of the rarest forms of endometriosis is abdominal wall endometriosis (AWE) which is characterized by the abnormal presence of endometrial tissue within the abdominal wall, generally superficial to the peritoneal fascia [2]