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Two of the cases involved specific circumstances that make it hard to say tirzepatide was definitively the only cause: A medication switch gone wrong: A 59-year-old with type 2 diabetes developed acute pancreatitis two days after their provider switched them from 1 mg semaglutide to a 7.5 mg dose of tirzepatide, skipping the recommended low starting dose entirely

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These results generated significant attention because they placed survodutide in the same approximate range as tirzepatide in early-stage data though Phase 2 and Phase 3 trials are not directly comparable in methodology or scale

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