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First-line pharmacological treatments include carbamazepine and oxcarbazepine

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ClinicalTrials.gov is the authoritative place to check if that ever changes

For loose skin specifically, this is huge

found that restoring histological abnormalities in ovarian and breast cancer rat models decreased serum MMP-1, NF-B, and TNF- levels (El-Beltagy et al., 2021)