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GLP-1 receptors are expressed in several tissues in the body, including the gastrointestinal tract, heart, lung, kidney, and brain

So, in addition to stimulating the body to produce more insulin like Januvia does, the metformin in Janumet causes the liver to produce less glucose and prevents the intestines from absorbing too much glucose

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Although advances in molecular typing and targeted therapies have improved the prognosis of patients with specific subtypes, the heterogeneity of AML, its driving mechanisms, and complex interactions between leukemia stem cells (LSCs) and the bone marrow microenvironment remain unclear (3)