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The point of the design is selectivity: because the fragment does not engage the growth-hormone receptor, it does not raise IGF-1 or disturb glucose handling the way full growth hormone can

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For instance, synthetic drugs are often derived from chemical reagents or scarce natural products dependent on non-renewable resources, whereas live bacterial drugs are predominantly sourced from readily available, biodegradable natural material [14, 15]

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Their primary drawbacks include high material costs, difficulties in large-scale production, and unpredictable in vivo biodistribution