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Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box

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June 24, 2025

Bhat R, Suchethana PS, Saldanha V, Yuktha SK, Patel NB, Shabaraya AR (2024) Anti-anxiety activity of hydroalcoholic extract of ficus religiosa leaves in experimental animals

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