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Of note, the effects of chronic activation or inhibition of POMC neurons differ between sexes, since female mice show resilience to chemogenetic manipulations of ARC POMC neurons despite similar electrophysiological changes under stress [151]

At Super Bowl LX, companies behind blockbuster GLP-1 medications spent tens of millions of dollars to court a mass audience

When plasma glucose levels are low, GLP-1RAs do not stimulate insulin secretion, which helps to maintain glycemic control while also reducing the risk of hypoglycemia [3, 4]

Am J Physiol Gastrointest Liver Physiol 2009;296:G115166

Two theories are most prominent- the amyloid beta (A) and the tau phosphorylation hypothesis