The medication works by: Slowing gastric emptying: This helps you feel fuller for longer after meals
By Lana Pine | Published on July 6, 2026 Fact checked by: Afton Woodward 4 min read GLP-1 receptor agonists like semaglutide and tirzepatide have helped millions of people lose significant weight and better manage blood sugar
74% female) underwent standardized LSG and was followed for five years with annual measurements of weight, BMI, %TWL, %EWL, GLP-1 and GIP
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Despite its benefits, the clinical application of orlistat is often hindered by its gastrointestinal side effects and modest weight loss results, prompting the search for alternative and adjunct therapies, including natural products and novel PL inhibitory peptides that may offer better tolerability and effectiveness in managing obesity [7,8,9]