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Unstable blood sugar levels can have a major impact on the adrenals, as a constant rollercoaster of high and low glucose levels creates enormous amounts of stress in the body

It may also help to reduce fatigue and support healthy weight management

Elderly patients might have decreased clearance and be more prone to nausea or dehydration, so timing should consider frailty and functional status

It is important that patients do not discontinue tirzepatide without medical advice if they suspect it may be affecting sexual function

If results are positive, Eli Lilly will likely submit a New Drug Application in late 2026 or early 2027