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GPX4-independent chondrocyte ferroptosis in OA Iron homeostasis is essential for joint health, and iron overload in joints has proved to be strongly associated with the pathogenesis of OA [110]

112,113 Therefore, careful family histories can provide important indices of suspicion in cases of unexplained cholestasis

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Clinical Evidence: REDEFINE Program# REDEFINE 1 (Without Type 2 Diabetes)# 3,417 adults randomized to CagriSema (n=2,108), semaglutide alone (n=302), cagrilintide alone (n=302), or placebo (n=705) for 68 weeks