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As GLP-1 receptor agonists (GLP-1s) like semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) become increasingly common in the treatment of diabetes, obesity, and cardiovascular disease, retina specialists are paying close attention to whether the drug therapies may influence ocular disease in already high-risk patients

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Concurrently, SCFAs enhance intestinal barrier integrity by upregulating tight junction proteins (e.g., occludin), which reduces systemic lipopolysaccharide (LPS) leakage and inhibits TLR4/NF-B-driven synovial inflammation (24, 25)

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