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Other Common Side Effects of Semaglutide Include: Decreased appetite Indigestion (dyspepsia) Fatigue Headache Belching or gas Injection site reactions (for injectable forms) Some reasons why you feel tired or fatigued after starting semaglutide medication include: Reduced Caloric Intake Semaglutide suppresses appetite, which can lead to significantly lower food intake

Perhaps its because of how they mix it with b12

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Tirzepatide reduces 24-hour ambulatory blood pressure in adults with body mass index 27 kg/m(2): SURMOUNT-1 ambulatory blood pressure monitoring substudy