fda compounding semaglutide enforcement october 2025 news Compounded Semaglutide: Legal & Safe Deadline nears for discounted weight

These GLP-1 medications are initially prescribed at a low dose, which increases over time

CMS may grant an ECE to one or more ASCs that have not requested an ECE if CMS determines that (i) A systemic problem with a CMS data collection system directly impacted the ability of the ASC to comply with a quality data reporting requirement

The magnitude of weight loss was dose-dependent, with the 2.4 mg dose showing a clinically meaningful reduction

Provides basic information that may be used as a rationale for treatments and care and allows for different teaching strategies

The study provided dosing exposure data but did not assess weight-loss efficacy or long-term safety endpoints