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Tirzepatide Unavailable: During shortage periods, semaglutide may be more accessible

GLP-1 agonists (Semaglutide, Tirzepatide) These FDA-approved medications have longer shelf life data

Patients should be advised to: Start with the lowest dose and increase slowly Eat smaller, more frequent meals Avoid high-fat foods Stay well-hydrated Safety monitoring should include vigilance for: Pancreatitis symptoms (severe persistent abdominal pain) discontinue immediately if suspected Gallbladder disease increased risk with rapid weight loss Hypoglycaemia particularly when combined with insulin or sulphonylureas Renal function deterioration especially with dehydration from gastrointestinal effects Diabetic retinopathy monitor in patients with pre-existing retinopathy, particularly with semaglutide Suspected adverse reactions should be reported via the MHRA Yellow Card scheme

Alternative pharmacological options include switching to a different FDA-approved weight management medication, as individual response varies between agents