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They found that CB-GLP-1 could relieve oxidative stress caused by astrocyte senescence through inhibiting the p53/p21 pathway [94]

The persistent accumulation of ROSarising from endogenous sources (e.g., mitochondrial leakage, enzymatic reactions) and exogenous insults (e.g., ultraviolet radiation, pollutants, tobacco)can overwhelm the antioxidant defense threshold, triggering widespread oxidative damage targeting proteins, lipids, and nucleic acids

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This suggests that an excess amount of L-carnitine to the maximum storage is required for effective prevention of lenvatinib-induced adverse effects in the skeletal muscle

Prompt treatment is essential to avoid complications