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This downregulated gene can mitigate the effects of IL-1 on the production of proinflammatory mediators, matrix MMP activity, and proteoglycan synthesis (Amin 2000)

doi: 10.4103/0253-7176.130960 6 DowellDRaganKRJonesCMBaldwinGTChouR

We show that melanoma induction by ultraviolet A (320400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes