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This may be explained by the findings of Albares and colleagues, Guinot and colleagues, and Kang and colleagues , who reported that pregnancy, use of hormonal contraception and lack of use of sunscreen are aggravating factors of melasma due to increase number and activity of melanocyte in epidermis

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10.1007/s00018-021-04061-9 251 YangS.YangG.WangX.XiangJ.KangL.LiangZ

Discontinue and seek immediate medical help