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In cases when patients are resistant to NSAIDs, intra-articular corticosteroid injections are contemplated

This is mechanism evidence, not outcome evidence

This release of secondary messenger molecules, such as IP3, might potentially stimulate the discharge of calcium ions (Ca2+) from the cells internal stores

Cytosolic Ca2+ signals can be viewed as the result of two opposing factors: influx into and efflux out of the cytosol (Sanders et al., 1999)