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Figure 5: Adjusted Mean HbA1c at Each Time Point (ITT, MMRM) and at Week 26 (ITT, LOCF) Placebo-Controlled Trial (Add-on to SGLT2i, with or without Metformin) In this 24-week placebo-controlled, double-blind trial, 423 adult patients were randomized to and received TRULICITY 0.75 mg, TRULICITY 1.5 mg, or placebo, as add-on to sodium-glucose co-transporter 2 inhibitor (SGLT2i) therapy (96% with and 4% without metformin)

[3][4] The attachment of a polyethylene glycol moiety to another chemical compound is termed Pegylation. Pegylation appears to increase the plasma stability of a compound like MGF by decreasing its clearance and potentially masking its immunogenicity

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doi: 10.1007/s11695-019-03845-0 87 MurphyG.McGuireM