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June 15, 2026 GLP-1 GI Injury MDL Reaches 3,763 Pending Cases The federal GLP-1 gastrointestinal injury MDL continues to grow

Paracetamol (maximum 4 g daily) is a safe first-line option for most patients, whilst ibuprofen (maximum 1.2 g daily for over-the-counter use) may be used if paracetamol proves insufficient, provided you have no contraindications such as kidney disease or gastric ulcer history

These washout periods ensure the medication is cleared from your system before pregnancy

Haupt E, Ledermann H, Kopcke W

Other factors expressed by astrocytes, including VEGF, glial cell derived neurotrophic factor (GDNF), and angiopoietin-1, mediate angiogenesis and recruitment of TJ proteins, contributing to BBB development and maintenance (Cabezas et al., 2014