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TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

The strongest direct gastric-emptying numbers in the amylin literature remain those from pramlintide, 3 10 and importing them wholesale onto a structurally modified, kinetically transformed molecule is exactly the kind of extrapolation this article is cautioning against

But eating less comes with an unexpected challenge

One in six of them will have an MI at that early age and they make up one in 250 of the population, he explains