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Insulin sensitivity improves and androgen levels fall Chronic metabolic strain can cause insulin resistance, a hallmark of PMOS

In T2D patients, insulin-mediated inhibition of lipolysis is thought to be impaired, thereby increasing plasma FA levels and ectopic accumulation of TAGs in key insulin sensitive tissues leading to insulin resistance (186)

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These medications, while sharing some mechanisms of action, are approved for distinct uses, underscoring the importance of individualized treatment plans for patients with diabetes and those looking for weight management solutions