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However, metformin also exerts anticancer effects and is thought to do this through both AMPK-dependent and AMPK-independent mechanisms 116

While glucose is the preferred substrate for energy production in retinal neurons, under certain circumstances, including cell degeneration and glucose-deprived conditions, they use alternate fuel substrates in order to improve metabolic efficiency 9,10,11

Integrating phytochemicals with conventional AD medications may improve therapeutic efficacy through synergistic mechanisms