Gradual deterioration of renal function leads to ESRD in the 4th to 5th decade, which is the primary cause of death in patients with untreated Fabry disease 9,10
Nausea is usually mild to moderate but can be more intense at higher doses
Conceptually, co-targeting lactate handling (LDH/MCTs) together with chromatin writing (p300/CBP) may be rational in lactate-high tumors or therapy-induced lactate rebound contexts, but it should be framed as a strategy to re-shape lactate-driven transcriptional and microenvironmental states, supported by orthogonal pharmacodynamic readouts (for example, site-specific Kla quantified by mass spectrometry or rigorously validated antibodies)
Another important direction has been the study of the islet secretome, which provides opportunities for identifying novel biomarkers and potential therapeutic targets (Shapira et al., 2022)
Discussing these factors with your providerand potentially integrating genetic insightshelps design a discontinuation plan matched to your metabolic profile rather than a calendar date
