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Key considerations for B12 intravenous dosing include: Initial dose: 1,000 mcg per infusion Frequency of administration: varies based on clinical need Monitoring of patient response to adjust dosing as necessary IV Infusion Methods and Duration B12 IV infusions are given slowly to avoid side effects
Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized
Typically, doctors prescribe a loading dose, which involves multiple injections administered close together, followed by maintenance doses to sustain adequate B12 levels over time