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However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch

Noh JS, Kim EY, Kang JS, Kim HR, Oh YJ, Gwag BJ

Its important physiological role was initially discerned in undifferentiated human embryonic stem cells (hESCs), where ChaC2 is prominently expressed and maintains cell self-renewal and pluripotency by modulating GSH homeostasis

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