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The sugar sensing neurons of the gut, the way the vagus is wired, the fact that Omega 3, Omega 6 tend to improve the ratios tend to impact mood, with high omega 3, omega 6 ratios improving mood

This is precisely what one might expect to see if GPX1 is a protease substrate , because its cleavage would produce two fragments that would necessarily have reduced affinity to the enzyme relative to GPX1

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[2] The gut microbiome connection is worth noting in this context