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Spermidine delays aging through multiple pathways, such as the activation of autophagy, the regulation of epigenetic modifications, the improvement of mitochondrial function and the inhibition of inflammation, and has shown potential for improving healthspan in model organisms (yeasts, Drosophila , nematodes, and mice) 429 and humans

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Aquat Toxicol 258:106510 Chen C, Li P, Liu L, Li Z (2022) Interactions between the gut microbiome and the shifting surrounding aquatic environment in fisheries and aquaculture: a review