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J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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The drug works by activating the GLP-1 receptors in the gastrointestinal tract, pancreas, and brain

Shortages of commercial GLP-1 drugs initially opened the door for compounding, but as supply chains recover, the rules are tightening

Females on SD had a slight body weight reduction compared to their starting weight, which was greater than the body-weight change seen in males on SD ( p = 0.022, Cohens d = 0.950)