According to a 2022 review, gastrointestinal side effects, including constipation, were among the most commonly reported adverse effects of GLP-1 receptor agonists, especially during the dose-escalation phase in about 25-35% of users
224 Several studies have reported various histone epigenetic modifications of metabolic and mitogenic cascade-related genes of insulin signaling during IR
Being on this list means: Athletes are not required to declare GLP-1 use No Therapeutic Use Exemption (TUE) is needed It is legal to use before, during, and after competition WADA is collecting prevalence data through anonymous sample analysis A substance can remain on the monitoring list for years before any decision is made Historically, substances spend 2-5 years on the monitoring program before WADA decides to either ban them or remove them from monitoring
Gas is a recognized side effect of semaglutide and usually appears as part of the broader gastrointestinal changes patients experience, especially early in treatment or during dose increases
Because these medications affect the central nervous system, plaintiffs contend that mental-health effects are a foreseeable safety concern, even where the exact level of risk is not fully defined