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A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities

However, important discoveries in fundamental and therapeutically relevant research should result from the inclusion of both sexes in animal research investigations

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During systemic inflammation, the BBB is impacted via numerous processes, such as, activation of matrix metalloproteinases (MMPs), oxidative stress and free radical damage, and direct effects of circulating cytokines on tight junction proteins