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More precisely, in early clinical trials, Retatrutide has shown the potential for significant weight loss, with participants on the highest dose losing an average of 28.7% of their body weight over 68 weeks, which is double the weight loss seen with other GLP-1 medications like Ozempic and Wegovy

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In nonclinical studies, the C-terminal Arg-Phe-Xaa peptidic motif common to RF-amide receptor ligands is associated with blood pressure and heart rate changes (152, 155158)

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