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NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2M) and can selectively bind to NNMT substrate binding site residues

Certain individuals are at a higher risk for B12 deficiencyincluding those following strict vegan or vegetarian diets, as well as patients with conditions that impair nutrient absorption, such as pernicious anemia, celiac disease, Crohns disease, or a history of gastrointestinal surgery

doi:10.1016/j.jtherbio.2022.103376

Several factors can lead to elevated B12 levels, including: Over-supplementation: The excessive intake of vitamin B12 through high-dose oral supplements or repeated intramuscular injections can raise blood levels of B12 temporarily 6