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Profiling of differentially expressed MCs and construction of a risk signature in HCC We analyzed mitochondrial carrier (MC) expression levels in tumor tissues versus adjacent normal tissues using the R package DESeq2 to identify differentially expressed MCs

Diagnosis Diagnosis is made based on clinical appearance and histopathology

However, the ominous octet as described by DeFronzo, suggests that multiple drugs targeting different metabolic abnormalities in type 2 diabetes are required to reduce subsequent morbidity and mortality [7]

Developed by Eli Lilly, initial phase 1 trials commenced in December 2016 ( Figure 1 ), with mazdutide first approved in China for weight management (June 2025) and glycaemic control in T2DM (September 2025)

Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors