Although red blood cells lack mitochondria, hepatocytes exhibit altered OXPHOS and tricarboxylic acid (TCA) cycle activity upon parasite infection (Evers et al., 2021)
Regarding the modulation of intracellular zinc levels, cells overexpressing zinc importers, such as SLC39A4 , SLC39A6 , and SLC39A10 , were significantly enriched, whereas the overexpression of the zinc exporters SLC30A4 and SLC30A1 led to depletion from the cell pool
Stomach upset Diarrhea Nausea Vomiting Fatigue Eye irritation Skin rash Less common: Low blood pressure, anaphylactic shock, asthma attacks, headache Case reports Light sensitivity: Occurred in pulmonary fibrosis patients taking NAC in combination with pirfenidone
doi: 10.1056/NEJMOA1603827 37 LeRNguyenMTAllahwalaMAPsaltisJPMaratheCSMaratheJAet al
Gland is also preparing for a larger play in the biologics business, focusing on expanding its biosimilar and biologic CDMO segment