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A positive response was considered quick retraction of the head or scratching of the face with the ipsilateral forepaw

A systematic review and meta-analysis of the effectiveness of meal replacements for weight loss

Ridker PM, Bhatt DL, Pradhan AD, Glynn RJ, MacFadyen JG, Nissen SE (2023) Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials

I think it is safe to say these are anti-inflammatory medications as well as weight loss and glucose controlling medications

Since both glucose and fatty acids could contribute to histone acetylation, we reasoned that this could occur either by two distinct substrate-specific mechanisms or a mechanism in which these substrates can feed into a common precursor acetyl-CoA pool (e.g., in mitochondria) that is then transported to the nuclear-cytosolic compartment (Supplemental Figure 5E)