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In 1997, Lee published a groundbreaking paper in the New England Journal of Medicine showing that acetaminophen was the leading cause of acute liver failure at Parkland Memorial hospital in Dallas, despite the drugs apparent overall safety. Not to be confused with chronic liver failure, such as that caused by alcoholism, acute liver failure is a sudden, often fatal condition that affects about 2,000 Americans each year

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These modifications can change the structure of protein and produce new epitopes, which may not be covered by central tolerance, so they can trigger immune response under certain conditions

La tecnologa de microencapsulacin o liposoma, proporcionada por Shaanxi Hongda, puede mejorar significativamente la biodisponibilidad oral

Ann Thorac Surg 2014