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The mechanisms driving central sensitization include elevated substance P, reduced descending pain inhibition, altered glutamate signaling, and microglial activation in the central nervous system

Its a tri-agonist targeting three separate receptor systems simultaneously: The GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

For example, its likely they wont lead to the same dramatic decrease in appetite

Efficacy of ketamine therapy in the treatment of depression