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Acknowledgements We dedicate this manuscript to the memory of Professor Vojtech Adam who tragically passed away during the preparation of this manuscript

Free radicals can damage melanocyte stem cells, thus reducing the number of melanocytes at the hair bulb This event is an example of a first-stage failure point, and it leads to melanocyte stem cell dysfunction (Jo et al., 2018)

It activates telomerase, the enzyme that maintains telomere length

This peptide was isolated in Zurich by Rinderknecht and Humbel on the basis of its insulin-like activity, but was renamed IGF-1 when it became apparent that its growth-promoting properties were more important than their insulin-like activities (Rinderknecht & Humbel, 1978)

In fact, by reducing oxidative stress, glutathione may help the skin recover more efficiently from the increased turnover caused by retinol