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Du K, Williams CD, McGill MR, Jaeschke H

Advantages: Less IV effect, more convenient, and less invasive, compared to a patient who might not like IV drips

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An animal study showed that NAC increased histamine release in conjunction with fluoride.[ref] In people given IV n-acetylcysteine in a hospital setting for acetaminophen poisoning, about 8% of the patients had an anaphylactoid reaction, defined as cutaneous (urticaria, pruritus, angioedema) or systemic (hypotension, respiratory symptoms) within five hours of receiving the IV