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Eventually the effectiveness of the epidural steroid injections, if effective at all would wear off

79 WangY.SunL.HeG.GangX.ZhaoX.WangG.et al (2021)

Your dose may need to increase as your body adapts and your provider titrates to your optimal therapeutic level

When the cell senses oxidative stress, Nrf2 responds by translocating from the cytoplasm to the nucleus, where it binds to the antioxidant-response elements located in the promoter regions of genes responsible for antioxidant production [68, 69]

There is evidence that serious adverse events, such as psychological distress, can also occur in non-pharmaceutical trials