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31,32,33,34 However, the complexity of the mechanism involving co-activators is beginning to be understood

The agency also identified gaps concerning characterisation, impurities, aggregates, pharmacokinetics, toxicology and immunogenicity

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Another study found that liraglutide also reduced the activation of microglial cells in the brain's cortex and thalamus in diabetic rats by lowering the expression of NLRP3 protein, a marker of inflammation in brain microglia [104]