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In contrast, many recent studies explored and demonstrated the implication of GSH depletion in induction of apoptosis via depletion of mitochondrial GSH pool leading to the release of cytochrome c, when combined with chemotherapy in breast cancer and leukemia, respectively (71, 72)

Clinical data from the CJC-1295 DAC trials showed dose-dependent GH increases of 2 to 10-fold lasting 6 days or more after a single injection

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